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. 2011 Mar;104(3):100-6.
doi: 10.1258/jrsm.2010.10k052.

The discovery of thyroid replacement therapy. Part 3: A complete transformation

Stefan Slater  1
Affiliations

The discovery of thyroid replacement therapy. Part 3: A complete transformation

Stefan Slater. J R Soc Med. 2011 Mar.
No abstract available

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Figures

Figure 1
Figure 1
An advanced case of myxoedema, age 73, before treatment in 1893. Note the swollen face, eyelids and lower lip, the almost bald scalp and the rough skin. Three months after the commencement of treatment the myxoedematous swelling had almost disappeared and the whole scalp was covered with dark hair, half an inch in length (from Bramwell 1895)
Figure 2
Figure 2
Sporadic cretinism in a 4-year-old girl, before (left) and 2 months after starting treatment with thyroid extract. Note the myxoedematous swelling of the whole body has almost entirely disappeared with treatment, the tongue is no longer protruberant, the expression is much brighter and the child is taller. The photographs have been reproduced exactly to scale so that the relative increase in height and diminution in girth before and after treatment are reliably shown (from Bramwell 1895)
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References

    1. Semon F. In discussion of ’A typical case of myxoedema’ by FD Drewitt in the Proceedings of the Clinical Society of London. BMJ 1883;ii:1072–4
    1. Rolleston HD The endocrine organs in health and disease with an historical review. Oxford: Oxford University Press; 1936
    1. Medvei VC. The History of Clinical Endocrinology: a comprehensive account of endocrinology from earliest times to the present day. Carnforth: Parthenon; 1993
    1. Semon HC, McIntyre TA, eds The autobiography of Sir Felix Semon. London: Jarrolds; 1926
    1. Clinical Society of London Report of a committee nominated December 14, 1883, to investigate the subject of myxoedema. Trans Clin Soc Lond 1888;21 Suppl.

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