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Review
. 2011 Mar;10(3):209-19.
doi: 10.1038/nrd3366.

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

Alan H Nagahara  1 , Mark H Tuszynski
Affiliations
Review

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

Alan H Nagahara et al. Nat Rev Drug Discov. 2011 Mar.

Abstract

The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TRKB) are actively produced and trafficked in multiple regions in the adult brain, where they influence neuronal activity, function and survival throughout life. The diverse presence and activity of BDNF suggests a potential role for this molecule in the pathogenesis and treatment of both neurological and psychiatric disorders. This article reviews the current understanding and future directions in BDNF-related research in the central nervous system, with an emphasis on the possible therapeutic application of BDNF in modifying fundamental processes underlying neural disease.

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References

    1. Exp Neurol. 2005 Aug;194(2):476-83 - PubMed
    1. Nature. 2002 Oct 17;419(6908):687-93 - PubMed
    1. Neuroscience. 2008 Sep 9;155(4):1070-8 - PubMed
    1. J Alzheimers Dis. 2009;16(3):649-56 - PubMed
    1. Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):73-5 - PubMed

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