[Absorption of phenol from aqueous solution through the skin in rats]

Abstract

The purpose of the investigation was to evaluate the skin absorption of phenol from aqueous solution in rats and the efficiency of two of my own protective creams devised for protection of skin exposed to aqueous solution of electrolytes. One of these creams was composed of hydrocarbons components, the other had in addition silicone oil and cetaceum. The creams were tested by the measurement of phenol diffusion in vitro and by the assessment of the dose of this compound absorbed through the skin of rats. Excretion of total phenol in urine was also measured. Absorption of phenol from aqueous solution was proportional to the concentration. Excretion of this compound in urine was correlated with the absorbed doses. The creams devised in our laboratory proved the reduction of phenol absorption through the skin by 36-44% when concentration of solution was 1000 mg%. The effectiveness of these creams was compared with the two brands available on the market. The two own preparations showed better protection than products of other manufactures.