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. 2011 Jan;60(1):25-9.
doi: 10.4097/kjae.2011.60.1.25. Epub 2011 Jan 28.

Effect of a small dose of propofol or ketamine to prevent coughing and laryngospasm in children awakening from general anesthesia

Hae Jin Pak  1 , Won Hyung Lee, Sung Mi Ji, Youn Hee Choi
Affiliations

Effect of a small dose of propofol or ketamine to prevent coughing and laryngospasm in children awakening from general anesthesia

Hae Jin Pak et al. Korean J Anesthesiol. 2011 Jan.

Abstract

Background: Coughing during emergence from general anesthesia may be detrimental in children. We compared the effect of a small dose of propofol or ketamine administered at the end of sevoflurane anesthesia on the incidence or severity of coughing in children undergoing a minimal invasive operation.

Methods: One hundred and eighteen children aged between 3 and 15 years, American Society of Anesthesiologists (ASA) status I, were enrolled in this randomized double blind study. Anesthesia was induced with propofol or ketamine and maintained with sevoflurane in N(2)O/O(2). Each group received propofol 0.25 mg/kg or ketamine 0.25 mg/kg and the control group received saline 0.1 ml/kg. The decision to perform tracheal extubation was based on specified criteria, including the resumption of spontaneous respiration. During emergence from anesthesia and extubation, coughing was observed and graded at predefined times.

Results: The incidence of emergence without coughing was higher in the propofol group than in the ketamine and control group (19%, 11% and 6%, respectively), whereas the incidence of severe coughing was higher in the control group than in propofol and ketamine group (17.14%, 10.0% and 6.98%, respectively).

Conclusions: The addition of propofol 0.25 mg/kg decreased the incidence of coughing after sevoflurane general anesthesia in children undergoing non-painful procedures.

Keywords: Cough; Ketamine; Propofol.

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Figures

Fig. 1
Fig. 1
Occurrence of cough (Grades 0-3) and the percentage of coughing events recorded in each group (propofol, ketamine, control). The table provides the absolute recorded numbers and proportions [n=number of Grades 0, 1, 2, or 3 coughing events recorded, irrespective of the time point of interest (%, proportion of the total number of coughing events in the group)]. Grade 0, no cough; Grade 1, mild cough; Grade 2, moderate cough; Grade 3, severe cough. Propofol vs control (P = 0.047). Ketamine vs control (P > 0.05) by Pearson χ2 tests.
See this image and copyright information in PMC

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