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Clinical Trial
. 2011 Sep;118(9):1329-33.
doi: 10.1007/s00702-011-0614-9. Epub 2011 Feb 27.

Elevation of total homocysteine levels in patients with Parkinson's disease treated with duodenal levodopa/carbidopa gel

Thomas Müller  1 , Constanze Jugel, Reinhard Ehret, Georg Ebersbach, Gunar Bengel, Siegfried Muhlack, Fabian Klostermann
Affiliations
Clinical Trial

Elevation of total homocysteine levels in patients with Parkinson's disease treated with duodenal levodopa/carbidopa gel

Thomas Müller et al. J Neural Transm (Vienna). 2011 Sep.

Abstract

Levodopa/carbidopa (LD/CD) application elevates total plasma homocysteine (thcys). We determined thcys-, LD- and 3-O-methyldopa (3-OMD) concentrations in 28 patients with Parkinson's disease (PD) on a LD/CD duodenal gel treatment. We found a distinct thcys increase (29.52 ± 28.98 μmol/l [median ± SD]) above the 15 μmol/l threshold and a significant (R = 0.7) correlation between LD and 3-OMD. thcys ascent was observed in relation with the onset of atherosclerosis, non-motor symptoms and polyneuropathy in PD patients in the long term.

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