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Review
. 2011 Jul;118(7):979-86.
doi: 10.1007/s00702-010-0562-9. Epub 2011 Feb 27.

Transcriptional regulation and multiple functions of MAO genes

Jean C Shih  1 , Jason Boyang Wu, Kevin Chen
Affiliations
Review

Transcriptional regulation and multiple functions of MAO genes

Jean C Shih et al. J Neural Transm (Vienna). 2011 Jul.

Abstract

Monoamine oxidase (MAO) A and MAO B are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide. These two isoenzymes have different but overlapping substrate and inhibitor specificities. MAO A and MAO B share 70% amino acid sequence identity and show different temporal and spatial expressions in both humans and mice. Abnormal MAO A or MAO B activity has been implicated in numerous neurological and psychiatric disorders. A better understanding of the transcriptional regulation of MAO A and MAO B genes may help explain the differential tissue-specific expression of these two isoenzymes and provide insights into the molecular basis of the disorders associated with MAO dysfunction. This review discusses the recent progress in the transcriptional regulation and multiple functions of MAO A and MAO B genes.

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Figures

Fig. 1
Fig. 1
A schematic diagram of the 2-kb promoter organization, transcriptional regulation and regulatory effects of MAO genes. The size is not proportional to the promoter structure
See this image and copyright information in PMC

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