Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Feb;16(2):020501.
doi: 10.1117/1.3536509.

In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry

Alejandro Garcia-Uribe, Elizabeth B Smith, Jun Zou, Madeleine Duvic, Victor Prieto, Lihong V Wang

In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry

Alejandro Garcia-Uribe et al. J Biomed Opt. 2011 Feb.

Abstract

In this letter, we report the first use of oblique incidence diffuse reflectance spectrometry to conduct in-vivo measurements of optical properties of three different types of pigmented skin lesions, including melanoma, dysplastic, and common nevi. Both absorption and reduced scattering coefficient spectra were estimated from the spatially resolved diffuse reflectance within the wavelength range of 455-765 nm for 144 pigmented skin lesions including 16 melanomas. The absorption and reduced scattering spectra were found to change with the malignancy of the skin lesions, which were generally higher for the malignant cases than the benign ones. Based on the measurement results, the physiological origin leading to the change of the absorption and scattering properties is also discussed.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Oblique incidence diffuse reflectance spectroscopy (OIDRS) system setup.
Figure 2
Figure 2
Sample spatially-resolved diffuse reflectance collected in-vivo form human skin.
Figure 3
Figure 3
(a) Average absorption coefficient spectra and average reduced scattering coefficient spectra and (b) for common nevi, dysplastic nevi, and melanoma. The error bars represent standard deviations.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. American Cancer Society, Cancer Facts & Figures 2009, http://www.cancer.org.
    1. Mourant J. R., Hielscher A. H., Eick A. A., Johnson T. M., and Freyer J. P., “Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells,” Cancer 84, 366–374 (1998).10.1002/(ISSN)1097-0142 - DOI - PubMed
    1. Mirabal Y. N., Chang S. K, Atkinson E. N., Malpica A., Follen M., and Richards-Kortum R., “Reflectance spectroscopy for in vivo detection of cervical precancer,” J. Biomed. Opt. 7, 587–594 (2002).10.1117/1.1502675 - DOI - PubMed
    1. Garcia-Uribe A., Kehtarnavaz N., Marquez G., Prieto V., Duvic M., and Wang L. V.. “Skin cancer detection by spectroscopic oblique-incidence reflectometry: classification and physiological origins,” Appl. Opt. 43, 2643–2650 (2004).10.1364/AO.43.002643 - DOI - PubMed
    1. Salomatina E., Jiang B., Novak J., and Yaroslavsky A. N., “Optical properties of normal and cancerous human skin in the visible and near-infrared spectral,” J. Biomed. Opt. 11(6), 064026 (2006).10.1117/1.2398928 - DOI - PubMed

Publication types

MeSH terms