Clever leukemic stem cells branch out
- PMID: 21362561
- DOI: 10.1016/j.stem.2011.02.015
Clever leukemic stem cells branch out
Abstract
Individual tumors harbor heterogeneous populations of genetically distinct subclones. Two recent papers in Nature by Notta et al. (2011) and Anderson et al. (2011) reveal genetic heterogeneity in functional leukemic stem cells, which has important implications for how both cancer and normal stem cell populations may adapt to selective pressure.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Genetic variegation of clonal architecture and propagating cells in leukaemia.Nature. 2011 Jan 20;469(7330):356-61. doi: 10.1038/nature09650. Epub 2010 Dec 15. Nature. 2011. PMID: 21160474
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Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells.Nature. 2011 Jan 20;469(7330):362-7. doi: 10.1038/nature09733. Nature. 2011. PMID: 21248843
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