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Comment
. 2011 Mar 4;8(3):246-7.
doi: 10.1016/j.stem.2011.02.013.

Safely modulating the immune system in regenerative medicine

Martin F Pera  1
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Safely modulating the immune system in regenerative medicine

Martin F Pera. Cell Stem Cell. .
Free article

Abstract

The destruction of pluripotent stem cell-derived grafts by the host immune system presents a significant barrier to clinical translation of cell therapies. Pearl et al. (2011) report in this issue of Cell Stem Cell that a brief, nontoxic immunosuppressive regimen, achieved by blockade of leucocyte costimulatory pathways, may overcome this problem.

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