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. 2011 Mar 4;8(3):262-5.
doi: 10.1016/j.stem.2011.02.012.

Phosphoryl-EZH-ion

Giuseppina Caretti  1 , Daniela Palacios, Vittorio Sartorelli, Pier Lorenzo Puri
Affiliations

Phosphoryl-EZH-ion

Giuseppina Caretti et al. Cell Stem Cell. .

Abstract

Polycomb group (PcG) proteins regulate gene expression in embryonic and adult stem cells, but the mechanisms responsible for PcG gene targeting and regulation remain largely unknown. Recent evidence shows that EZH2, the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), is a nuclear phosphoprotein linking cell-cycle-intrinsic or extracellular signals to specific epigenetic signatures.

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Figures

Figure 1
Figure 1
Illustrative Scheme of Phosphorylation Sites on EZH2, Their Respective Kinases, and Functional Outcomes
See this image and copyright information in PMC

References

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