Urogenital schistosomiasis in women of reproductive age in Tanzania's Lake Victoria region

Abstract

We conducted a community-based study of 457 women aged 18-50 years living in eight rural villages in northwest Tanzania. The prevalence of female urogenital schistosomiasis (FUS) was 5% overall but ranged from 0% to 11%. FUS was associated with human immunodeficiency virus (HIV) infection (odds ratio [OR] = 4.0, 95% confidence interval [CI] = 1.2-13.5) and younger age (OR = 5.5 and 95% CI = 1.2-26.3 for ages < 25 years and OR = 8.2 and 95% CI = 1.7-38.4 for ages 25-29 years compared with age > 35 years). Overall HIV prevalence was 5.9% but was 17% among women with FUS. We observed significant geographical clustering of schistosomiasis: northern villages near Lake Victoria had more Schistosoma mansoni infections (P < 0.0001), and southern villages farther from the lake had more S. haematobium (P = 0.002). Our data support the postulate that FUS may be a risk factor for HIV infection and may contribute to the extremely high rates of HIV among young women in sub-Saharan Africa.

Figure 1.

Map of the Mwanza region in Tanzania's Lake Victoria region with village locations. Northern villages nearer to Lake Victoria, with lower rates of S. haematobium and higher rates of S. mansoni, are depicted with yellow dots. Southern villages, with higher rates of S. haematobium and no S. mansoni infection detected, are depicted with red dots.