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. 2011 Jun;90(6):735-9.
doi: 10.1177/0022034510397614. Epub 2011 Mar 1.

A major gene effect controls resistance to caries

R I Werneck  1 , F P Lázaro, A Cobat, A V Grant, M B Xavier, L Abel, A Alcaïs, P C Trevilatto, M T Mira
Affiliations

A major gene effect controls resistance to caries

R I Werneck et al. J Dent Res. 2011 Jun.

Abstract

Despite recent advances revealing genetic factors influencing caries susceptibility, questions regarding the model of inheritance involved are yet to be addressed. We conducted a Complex Segregation Analysis on decayed teeth in a sample of homogenous, isolated families recruited from the Brazilian Amazon. A dominant, major gene effect controlling resistance to phenotype was detected. The frequency of the resistance allele "A" was 0.63; mean numbers of decayed teeth were 1.53 and 9.53 for genotypes AA/AB and BB, respectively. These results represent a step toward a description of the exact nature of the genetic risk factors controlling human susceptibility to caries.

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