Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Mar;13(3):197-9.
doi: 10.1038/ncb0311-197.

Necrotic cell death: harnessing the Dark side of the Force in mammary gland involution

Cliff J Luke, Gary A Silverman
Comment

Necrotic cell death: harnessing the Dark side of the Force in mammary gland involution

Cliff J Luke et al. Nat Cell Biol. 2011 Mar.

Abstract

In response to major cellular insults, a massive increase in lysosomal membrane permeability (LMP) leads to necrosis. Data now reveal that this potent lysosomal-mediated necrotic cell-death machinery can also be harnessed for complex physiological processes, such as post-lactation mammary gland involution.

PubMed Disclaimer

Comment on

  • Stat3 controls lysosomal-mediated cell death in vivo.
    Kreuzaler PA, Staniszewska AD, Li W, Omidvar N, Kedjouar B, Turkson J, Poli V, Flavell RA, Clarkson RW, Watson CJ. Kreuzaler PA, et al. Nat Cell Biol. 2011 Mar;13(3):303-9. doi: 10.1038/ncb2171. Epub 2011 Feb 20. Nat Cell Biol. 2011. PMID: 21336304

References

    1. Gene. 1991 Oct 15;106(2):213-20 - PubMed
    1. Cancer Res. 2008 Aug 15;68(16):6623-33 - PubMed
    1. Mol Cell. 2004 Apr 23;14(2):207-19 - PubMed
    1. Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1371-87 - PubMed
    1. Genes Dev. 1999 Oct 1;13(19):2604-16 - PubMed

LinkOut - more resources