Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Feb;6(2):203-16.
doi: 10.2217/fmb.10.165.

Genotyping of Mycobacterium tuberculosis: application in epidemiologic studies

Midori Kato-Maeda  1 , John Z Metcalfe, Laura Flores
Affiliations
Review

Genotyping of Mycobacterium tuberculosis: application in epidemiologic studies

Midori Kato-Maeda et al. Future Microbiol. 2011 Feb.

Abstract

Genotyping is used to track specific isolates of Mycobacterium tuberculosis in a community. It has been successfully used in epidemiologic research (termed 'molecular epidemiology') to study the transmission dynamics of TB. In this article, we review the genetic markers used in molecular epidemiologic studies including the use of whole-genome sequencing technology. We also review the public health application of molecular epidemiologic tools.

PubMed Disclaimer

References

Bibliography

    1. Rauillon A, Perdrizet S, Parrot R. Transmission of tubercle bacilli: the effects of chemotherapy. Tubercle. 1976;57(4):275–299. - PubMed
    1. Houk VN, Baker JH, Sorensen K, Kent DC. The epidemiology of tuberculosis infection in a closed environment. Arch Environ Health. 1968;16(1):26–35. - PubMed
    1. Centers for Disease Control and Prevention. Targeted tuberculin testing and treatment of latent tuberculosis infection. American Thoracic Society. MMWR Recomm Rep. 2000;49(RR-6):1–51. - PubMed
    1. Foxman B, Riley L. Molecular epidemiology: focus on infection. Am J Epidemiol. 2001;153(12):1135–1141. - PubMed
    1. Houben RM, Glynn JR. A systematic review and meta-analysis of molecular epidemiological studies of tuberculosis: development of a new tool to aid interpretation. Trop Med Int Health. 2009;14(8):892–909. - PubMed

Websites

    1. WHO. Tuberculosis. Fact Sheet No. 104. www.who.int/mediacentre/factsheets/fs104/en/
    1. WHO. WHO Report 2009. WHO; Geneva: 2009. Global tuberculosis control – epidemiology, strategy, financing. www.who.int/tb/publications/global_report/2009/en/lindex.html.
    1. Institut Pasteur De La Guadeloupe. Tuberculose et Mycobactéries. www.pasteur-guadeloupe.fr/tb/bd_myeo.html.
    1. MIRU-VNTRplus. www.miru-vntrplus.org/

MeSH terms