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Comment
. 2011 Apr 15;17(8):2071-3.
doi: 10.1158/1078-0432.CCR-11-0211. Epub 2011 Mar 2.

Targeting the Hedgehog pathway in cancer: can the spines be smoothened?

Laurie Ailles  1 , Lillian L Siu
Affiliations
Comment

Targeting the Hedgehog pathway in cancer: can the spines be smoothened?

Laurie Ailles et al. Clin Cancer Res. .

Abstract

Aberrant Hedgehog (Hh) pathway signaling has been suggested to play a role in the development of multiple solid tumors and hematologic malignancies. GDC-0449 is a novel first-in-human, first-in-class smoothened (SMO) inhibitor, which has completed its phase I evaluation and achieved proof of concept in tumors with Hh pathway mutations.

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