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. 2011 May;49(5):2027-30.
doi: 10.1128/JCM.00084-11. Epub 2011 Mar 2.

Discriminating Lyme neuroborreliosis from other neuroinflammatory diseases by levels of CXCL13 in cerebrospinal fluid

N D van Burgel  1 , F Bakels, A C M Kroes, A P van Dam
Affiliations

Discriminating Lyme neuroborreliosis from other neuroinflammatory diseases by levels of CXCL13 in cerebrospinal fluid

N D van Burgel et al. J Clin Microbiol. 2011 May.

Abstract

CXCL13 in cerebrospinal fluid (CSF) could be an important component for diagnosing Lyme neuroborreliosis (LNB). Levels of intrathecal CXCL13 were determined for 58 LNB patients and 210 controls; sensitivity was 88% and specificity was 89% (cutoff, 250 pg of CXCL13/ml of CSF). Elevated levels of CXCL13 can aid in the diagnosis of LNB, but levels should be interpreted with care.

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Figures

Fig. 1.
Fig. 1.
Levels of CXCL13 in CSF of LNB patients and controls. Horizontal lines indicate medians, bars represent interquartile ranges, lines represent the 95% confidence interval, and open circles represent outliers. The reference line is located at the cutoff of 250 pg/ml as determined by ROC curve analysis for optimal sensitivity and specificity for discriminating LNB patients from controls. T. pallidum, Treponema pallidum; C. neoformans, Cryptococcus neoformans; S. pneumoniae, Streptococcus pneumoniae; L. monocytogenes, Listeria monocytogenes; M. tuberculosis, Mycobacterium tuberculosis; VZV, varicella-zoster virus; HSV, herpes simplex virus; TBE, tick-borne encephalitis virus.
Fig. 2.
Fig. 2.
ROC curve analysis using levels of CXCL13 to discriminate between LNB patients and all controls. Horizontal lines show three different cutoff values for levels of CXCL13. The optimal cutoff was 250 pg/ml.
See this image and copyright information in PMC

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