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Review
. 2011 Jun;13(3):225-32.
doi: 10.1007/s11883-011-0173-4.

Genome-wide association studies in atherosclerosis

S Sivapalaratnam  1 , M M Motazacker, S Maiwald, G K Hovingh, J J P Kastelein, M Levi, M D Trip, G M Dallinga-Thie
Affiliations
Review

Genome-wide association studies in atherosclerosis

S Sivapalaratnam et al. Curr Atheroscler Rep. 2011 Jun.

Abstract

Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role. In recent years, large genome-wide association studies have been conducted to decipher the molecular mechanisms underlying this heritable and prevalent phenotype. The emphasis of this review is on the recently identified 17 susceptibility loci for coronary artery disease. Implications of their discovery for biology and clinical medicine are discussed. A description of the landscape of human genetics in the near future in the context of next-generation sequence technologies is provided at the conclusion of this review.

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Figures

Fig. 1
Fig. 1
Proposed sites of action for the proteins involved in the pathogenesis of atherosclerosis: liver, vessel wall, plaque and thrombus
See this image and copyright information in PMC

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