Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 May;65(5):449-51.
doi: 10.1002/syn.20896.

Ephedrine decreases vesicular monoamine transporter-2 function

Jonathan D Ellis  1 , Christopher L German, Elisabeth Birdsall, Jarom E Hanson, Marcus A Crosby, Shane D Rowley, Nicole A Sawada, Jeremiah N West, Glen R Hanson, Annette E Fleckenstein
Affiliations

Ephedrine decreases vesicular monoamine transporter-2 function

Jonathan D Ellis et al. Synapse. 2011 May.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Panel A: Rats received ephedrine (3 injections, 5 – 25 mg/kg/injection, s.c., 2-h intervals, n = 6) or saline vehicle (3 injections, 1 ml/kg/injection, s.c., 2-h intervals, n = 6) and were sacrificed 1 h later. Panels B and C: Rats received ephedrine (3 injections, 25 mg/kg/injection, s.c., 2-h intervals, n = 5–10) or saline vehicle (zero-time controls; 3 injections, 1 ml/kg/injection, s.c., 2-h intervals, n=5–10) and were sacrificed 1 – 168 h later. Values represent the means ± SEM. * Value significantly different from saline-treated controls (p ≤0.05).
See this image and copyright information in PMC

References

    1. Bowyer JF, Newport GD, Slikker W, Jr, Gough B, Ferguson SA, Tor-Agbidye J. An evaluation of l-ephedrine neurotoxicity with respect to hyperthermia and caudate/putamen microdialysate levels of ephedrine, dopamine, serotonin, and glutamate. Toxicol. Sci. 2000;55:133–142. - PubMed
    1. Brown JM, Hanson GR, Fleckenstein AE. Methamphetamine rapidly decreases vesicular dopamine uptake. J. Neurochem. 2000;74:2221–2223. - PubMed
    1. Brown JM, Hanson GR, Fleckenstein AE. Cocaine-induced increases in vesicular dopamine uptake: role of dopamine receptors. J. Pharmacol. Exp. Ther. 2001;298:1150–1153. - PubMed
    1. Brown JM, Riddle EL, Sandoval V, Weston RK, Hanson JE, Crosby MJ, Ugarte YV, Gibb JW, Hanson GR, Fleckenstein AE. A single methamphetamine administration rapidly decreases vesicular dopamine uptake. J. Pharmacol. Exp. Ther. 2002;302:497–501. - PubMed
    1. Brown JM, Yamamoto BK. Effects of amphetamines on mitochondrial function: role of free radicals and oxidative stress. Pharmacol. Ther. 2003;99:45–53. - PubMed

Publication types