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. 2011 Mar 7;50(11):2597-600.
doi: 10.1002/anie.201006849. Epub 2011 Feb 18.

Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus

Ming Yang  1 , Samuel K Lai, Ying-Ying Wang, Weixi Zhong, Christina Happe, Michael Zhang, Jie Fu, Justin Hanes
Affiliations

Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus

Ming Yang et al. Angew Chem Int Ed Engl. .
No abstract available

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Figures

Figure 1
Figure 1
Transport behavior of uncoated and Pluronic-coated PLGA particles in fresh human CVM. Representative trajectories of a) uncoated PLGA particles, b) particles coated with low PPO MW Pluronic (F68, F38 or P65) and c) particles coated with high PPO MW Pluronic (F127, P103 or P105). d) Phase diagram correlating muco-inert vs. mucoadhesive particle behavior to Pluronic PPO and PEG segment MW. Filled symbols indicate MPP formulations, while open symbols indicate mucoadhesive formulations.
Figure 2
Figure 2
Muco-inert vs. mucoadhesive behavior of PLGA particles coated with various Pluronics (F38, P65, P103, P105, F68 and F127) in fresh human CVM. a–c) Correlation between the zeta potential of Pluronic-coated PLGA particles and the MW of the a) PPO segment, b) PEG segment or c) entire Pluronic molecule. “Water” indicates the zeta potential of uncoated PLGA particles made in water. Filled symbols indicate MPP formulations, while open symbols indicate mucoadhesive formulations. r represents the correlation coefficient.
Figure 3
Figure 3
Transport of uncoated and F127-coated PLGA particles in human CVM. a) Ensemble-averaged geometric mean square displacements () as a function of time scale. b) Distributions of the logarithms of individual particle effective diffusivities (Deff) at a time scale of 1 s. * denotes statistically significant difference across all time scales (p < 0.05). c) Estimated fraction of particles predicted to be capable of penetrating a 30 μm thick mucus layer over time.
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