(R)-methadone versus racemic methadone: what is best for patient care?
- PMID: 21371149
- PMCID: PMC3723395
- DOI: 10.1111/j.1360-0443.2011.03374.x
(R)-methadone versus racemic methadone: what is best for patient care?
Abstract
Methadone has been linked to cardiac arrhythmia. (R)-methadone appears to confer a lower risk of QT interval prolongation, resulting in debate over how best to treat patients needing this medication. A discussion of salient aspects of selecting therapy for opioid dependence and pain management and decision-making regarding methadone formulation follows.
References
-
- Dole VP, Nyswander M. A medical treatment for diacetyl-morphine (heroin) addiction: a clinical trial with methadone hydrochloride. JAMA. 1965;193:646–50. - PubMed
-
- Taylor WF, Finkel AG, Robertson KR, Anderson AC, Toomey TC, Abashian SA, et al. Methadone in the treatment of chronic, nonmalignant pain: a 2-year follow-up. Pain Med. 2000;1:254–9. - PubMed
-
- Krantz MJ, Martin J, Stimmel B, Mehta D, Haigney MCP. QTc interval screening in methadone treatment. Ann Int Med. 2009;150:387–95. - PubMed
-
- Zunkler BJ, Wos-Maganga M. Comparison of the effects of methadone and heroin on human ether-á-go-go-related gene channels. Cardiovasc Toxicol. 2010;10:161–5. - PubMed
-
- Lin C, Somberg T, Molnar J, Somberg J. The effects of chiral isolates of methadone on the cardiac potassium channel IKr. Cardiology. 2009;113:59–65. - PubMed
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