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Review
. 2011 Apr 30;63(4-5):324-30.
doi: 10.1016/j.addr.2011.01.013. Epub 2011 Mar 1.

Induced pluripotent stem cells for regenerative cardiovascular therapies and biomedical discovery

Ali Nsair  1 , W Robb MacLellan
Affiliations
Review

Induced pluripotent stem cells for regenerative cardiovascular therapies and biomedical discovery

Ali Nsair et al. Adv Drug Deliv Rev. .

Abstract

The discovery of induced pluripotent stem cells (iPSC) has, in the short time since their discovery, revolutionized the field of stem cell biology. This technology allows the generation of a virtually unlimited supply of cells with pluripotent potential similar to that of embryonic stem cells (ESC). However, in contrast to ESC, iPSC are not subject to the same ethical concerns and can be easily generated from living individuals. For the first time, patient-specific iPSC can be generated and offer a supply of genetically identical cells that can be differentiated into all somatic cell types for potential use in regenerative therapies or drug screening and testing. As the techniques for generation of iPSC lines are constantly evolving, new uses for human iPSC are emerging from in-vitro disease modeling to high throughput drug discovery and screening. This technology promises to revolutionize the field of medicine and offers new hope for understanding and treatment of numerous diseases.

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Figures

Figure 1
Figure 1
Differentiated somatic cells (fibroblasts) can be reprogrammed into induced pluripotent stem cells (iPSC) with retroviral over-expression of the four factors Oct4, Sox2, Klf4, c-Myc. iPSC have the potential to differentiate into all somatic cell types.
Figure 2
Figure 2
Schematic outline of potential therapeutic applications of iPSC. iPSC can be differentiated into cardiomyocytes for drug screening and discovery. Autologous or haplotype matched iPSC-derived cells can be used for myocardial regenerative therapies post myocardial infarction. iPSC can be derived from specific patients to recreate the disease-in-a-dish models in-vitro for study.
See this image and copyright information in PMC

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