doi: 10.1038/343437a0.
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus
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- PMID: 2137203
- DOI: 10.1038/343437a0
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Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus
Nature.
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Abstract
A monoclonal antibody raised against mammalian spliceosomes specifically recognizes a non-snRNP factor required for spliceosome assembly. This splicing factor is highly concentrated in discrete regions within the nucleus, in a pattern that is a distinct subset of that seen with anti-snRNP antibodies. These observations are evidence that spliceosome assembly could be compartmentalized within the nucleus.
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