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. 1990 Feb 1;343(6257):437-41.
doi: 10.1038/343437a0.

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

X D Fu  1 , T Maniatis
Affiliations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

X D Fu et al. Nature. .

Abstract

A monoclonal antibody raised against mammalian spliceosomes specifically recognizes a non-snRNP factor required for spliceosome assembly. This splicing factor is highly concentrated in discrete regions within the nucleus, in a pattern that is a distinct subset of that seen with anti-snRNP antibodies. These observations are evidence that spliceosome assembly could be compartmentalized within the nucleus.

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