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Clinical Trial
. 1990 Feb;18(2):75-81.
doi: 10.1016/0165-0327(90)90062-d.

Hypercarbia versus hypocarbia in panic disorder

J Zandbergen  1 , H H Lousberg, H Pols, C de Loof, E J Griez
Affiliations
Clinical Trial

Hypercarbia versus hypocarbia in panic disorder

J Zandbergen et al. J Affect Disord. 1990 Feb.

Abstract

In order to compare the panicogenic effects of hypercarbia and hypocarbia in panic disorder (PD), 12 PD patients and 11 healthy controls underwent a 35% CO2 challenge as well as a hyperventilation provocation test in a random cross-over design. Both anxiety and anxiety symptoms proved to be significantly higher during the 35% CO2 challenge in PD patients as compared to the response during 35% CO2 in normals and during hyperventilation in both patients and normals. The results suggest that PD patients are specifically hypersensitive to an increase in pCO2.

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