doi: 10.1016/j.bmcl.2011.02.036.
Epub 2011 Feb 13.
Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity
Affiliations
- PMID: 21376588
- DOI: 10.1016/j.bmcl.2011.02.036
Item in Clipboard
Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity
Bioorg Med Chem Lett.
.
Abstract
Three indole alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity. This is the first example of CB1 antagonists derived from natural alkaloids.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Similar articles
-
Asymmetric total synthesis of an iboga-type indole alkaloid, voacangalactone, newly isolated from Voacanga africana.Org Lett. 2012 Nov 16;14(22):5800-3. doi: 10.1021/ol3027945. Epub 2012 Nov 6. Org Lett. 2012. PMID: 23131084
-
Cytotoxic monoterpenoid indole alkaloids isolated from the barks of Voacanga africana Staph.Nat Prod Res. 2016;30(10):1144-9. doi: 10.1080/14786419.2015.1046132. Epub 2015 Jul 3. Nat Prod Res. 2016. PMID: 26140390
-
Discovery of cannabinoid-1 receptor antagonists by virtual screening.Bioorg Med Chem Lett. 2010 Sep 1;20(17):5130-2. doi: 10.1016/j.bmcl.2010.07.018. Bioorg Med Chem Lett. 2010. PMID: 20667724
-
Chemistry and biology of the genus Voacanga.Pharm Biol. 2012 Sep;50(9):1183-93. doi: 10.3109/13880209.2012.658478. Epub 2012 Jul 26. Pharm Biol. 2012. PMID: 22834977 Review.
-
Structural biology in plant natural product biosynthesis--architecture of enzymes from monoterpenoid indole and tropane alkaloid biosynthesis.Nat Prod Rep. 2007 Dec;24(6):1382-400. doi: 10.1039/b711935f. Epub 2007 Oct 24. Nat Prod Rep. 2007. PMID: 18033585 Review.
Cited by
-
Indole alkaloids from marine sources as potential leads against infectious diseases.Biomed Res Int. 2014;2014:375423. doi: 10.1155/2014/375423. Epub 2014 Jun 5. Biomed Res Int. 2014. PMID: 24995289 Free PMC article. Review.
-
Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development.Evid Based Complement Alternat Med. 2015;2015:238482. doi: 10.1155/2015/238482. Epub 2015 Nov 17. Evid Based Complement Alternat Med. 2015. PMID: 26664449 Free PMC article. Review.
-
Carbene-catalyzed enantioselective oxidative coupling of enals and di(hetero)arylmethanes.Chem Sci. 2018 Sep 18;9(46):8711-8715. doi: 10.1039/c8sc03480j. eCollection 2018 Dec 14. Chem Sci. 2018. PMID: 30595836 Free PMC article.
-
Functionally-instructed modifiers of response to ATR inhibition in experimental glioma.J Exp Clin Cancer Res. 2024 Mar 12;43(1):77. doi: 10.1186/s13046-024-02995-z. J Exp Clin Cancer Res. 2024. PMID: 38475864 Free PMC article.
-
Identification of a Potent and Selective Cannabinoid CB1 Receptor Antagonist from Auxarthron reticulatum.ACS Med Chem Lett. 2011 Sep 17;2(11):866-9. doi: 10.1021/ml200183z. eCollection 2011 Nov 10. ACS Med Chem Lett. 2011. PMID: 24900275 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Chemical Information
