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. 2011 Apr 1;21(7):1962-4.
doi: 10.1016/j.bmcl.2011.02.036. Epub 2011 Feb 13.

Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity

Mariko Kitajima  1 , Masumi Iwai, Ruri Kikura-Hanajiri, Yukihiro Goda, Mitsuru Iida, Hisatoshi Yabushita, Hiromitsu Takayama
Affiliations

Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity

Mariko Kitajima et al. Bioorg Med Chem Lett. .

Abstract

Three indole alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity. This is the first example of CB1 antagonists derived from natural alkaloids.

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