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Review
. 2011 Jun;21(3):335-41.
doi: 10.1016/j.sbi.2011.02.003. Epub 2011 Mar 4.

Recognizing and remodeling the nucleosome

Sebastian Glatt  1 , Claudio Alfieri, Christoph W Müller
Affiliations
Review

Recognizing and remodeling the nucleosome

Sebastian Glatt et al. Curr Opin Struct Biol. 2011 Jun.

Abstract

The X-ray structure of the nucleosome core particle (NCP) has been a major milestone in the structural biology of chromatin. Since, our understanding how NCPs interact with multiple partners has been extending from single chromatin-binding domains recognizing post-translational modifications (PTMs) in histone tails towards the recognition of higher-order chromatin structure by multi-subunit chromatin remodeling complexes. The current review summarizes recent progress in the structural biology of nucleosome-recognition from chromatin-binding domains to multi-protein remodeling complexes.

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