Elevated serum uric acid predicts impaired fasting glucose and type 2 diabetes only among Japanese women undergoing health checkups

Abstract

Aim: This study assessed whether or not elevated serum uric acid can predict impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM) in Japanese people undergoing health checkups.

Methods: Altogether, 7114 male and 5529 female participants in both 2000 and 2005 were targeted for the study. After excluding those with IFG and T2DM, multiple logistic-regression analyses of 6408 men and 5309 women-average ages 48.4±10.2 and 50.0±9.1 years, respectively-were performed to identify independent risk factors for newly diagnosed IFG and T2DM in 2005, after adjusting for age, parental history of diabetes, body mass index (BMI), elevated blood pressure or hypertension, fatty liver, hypertriglyceridaemia, alcohol consumption and smoking status.

Results: Prevalence rates for IFG and T2DM, and values for BMI, systolic and diastolic blood pressure, fasting blood glucose and triglycerides, showed significantly increasing trends in relation to serum uric acid quartiles in both genders. IFG and T2DM were newly diagnosed in 8.1% of men and 4.0% of women in 2005. Using multivariate models, the highest quartile of serum uric acid and increases in serum uric acid were independent risk factors, but only in women. Serum uric acid was not a risk factor in men when categorized by the cut-off values of 4.8 mg/dL, the limit for the highest quartile in women, and of 7.0 mg/dL.

Conclusion: Elevated serum uric acid predicted IFG and T2DM only in Japanese women undergoing regular health checkups.