Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990;25(6):449-53.
doi: 10.1007/BF00686058.

Ondansetron--a new safe and effective antiemetic in patients receiving high-dose melphalan

C V Viner  1 , P J Selby, G B Zulian, M E Gore, M E Butcher, C M Wootton, T J McElwain
Affiliations

Ondansetron--a new safe and effective antiemetic in patients receiving high-dose melphalan

C V Viner et al. Cancer Chemother Pharmacol. 1990.

Abstract

A total of 33 patients with myeloma receiving treatment with high-dose melphalan (140-200 mg/m2 i.v.) were given the 5HT3 antagonist Ondansetron (Glaxo) as an antiemetic. In 42% of patients, emetic episodes were either abolished (15%) or reduced to two or less (27%). Efficacy was not related to scheduling (two regimens) or total dose. No sedative or other significant side effects were seen. Ondansetron is a highly effective non-sedative antiemetic that justifies further assessment in combination with other antiemetics in patients receiving cytotoxic drugs associated with the production of severe nausea and vomiting.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lancet. 1987 Jun 27;1(8548):1461-3 - PubMed
    1. Lancet. 1983 Oct 8;2(8354):822-4 - PubMed
    1. J Clin Oncol. 1986 Apr;4(4):612 - PubMed
    1. J Clin Oncol. 1988 Apr;6(4):659-62 - PubMed
    1. J Natl Cancer Inst. 1989 Jan 4;81(1):42-6 - PubMed

Publication types

MeSH terms

LinkOut - more resources