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. 2011 Apr 1;13(7):1746-9.
doi: 10.1021/ol2002682. Epub 2011 Mar 7.

A new synthesis of pyrazoles through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with monosubstituted hydrazines

Gang Shan  1 , Pengfei Liu, Yu Rao
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A new synthesis of pyrazoles through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with monosubstituted hydrazines

Gang Shan et al. Org Lett. .

Abstract

A new efficient and convenient approach toward the synthesis of pyrazoles is described. Through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with monosubstituted hydrazines, a variety of pyrazole derivatives were prepared readily at ambient temperature with complete regioselectivity.

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