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. 2011 Aug;38(4):277-80.
doi: 10.1111/j.1744-313X.2011.01001.x. Epub 2011 Mar 7.

Identification of two novel HLA-B*40 alleles, B*40:137 and B*40:158, in Taiwanese individuals

K L Yang  1 , S K Lee, C C Chu, C C Lin, S Jiang, H M Chiu, S Lin, Y C Chen, M J Chen, Y F Jian, C F Yang, S Y Yang, M H Shyr, C L Lin, P Y Lin
Affiliations

Identification of two novel HLA-B*40 alleles, B*40:137 and B*40:158, in Taiwanese individuals

K L Yang et al. Int J Immunogenet. 2011 Aug.

Abstract

Using sequence-based typing method we discovered two new HLA-B*40 variants, B*40:137 and B*40:158, in Taiwanese individuals. The sequence of B*40:137 has three nucleotide (nt) changes from B*40:21 at nt 353 (C→T), nt 355 (C→A) and nt 369 (C→T) resulting two coding changes at residue 94 (T→I) and residue 95 (L→I), whereas the sequence of B*40:158 differs from B*40:01:01 with five nt substitutes at nt 463 (C→A), nt 477 (C→G), nt 499 (T→A), nt 512 (T→G) and nt 527 (T→A) causing five amino acid exchanges at codons 140 (Y→S), 155 (R→S), 168 (S→T), 171 (L→W) and 179 (V→E). Our hypotheses on the generation of the two novel alleles are presented.

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