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. 2011 May;55(5):1827-30.
doi: 10.1128/AAC.01296-10. Epub 2011 Mar 7.

Resistance to chloroquine unhinges vivax malaria therapeutics

J Kevin Baird  1
Affiliations

Resistance to chloroquine unhinges vivax malaria therapeutics

J Kevin Baird. Antimicrob Agents Chemother. 2011 May.
No abstract available

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Figures

Fig. 1.
Fig. 1.
Drug-drug interaction between pamaquine and quinacrine, 1942. These data are for a single human subject characterized as typical of many others in the original confidential report (9). The boxes indicate days of dosing of pamaquine (10 mg every 4 h), quinine (600 mg every 8 h), or quinacrine (100 mg every 8 h). The administration of quinacrine but not of quinine caused a 10-fold elevation in plasma concentrations of pamaquine.
Fig. 2.
Fig. 2.
Relapse among 57 Caucasian subjects (19/group) in the United States who were challenged with sporozoites of the Chesson strain of P. vivax and randomized to three treatment arms represented by each line in the graph, as follows: 14 days of 2 g quinine daily followed by a 2-day pause and then 14 days of 15 mg primaquine daily (dashed line); precisely the same quinine and primaquine therapies except administered on the same days (solid line); and 1 g of chloroquine administered on the first of 14 days of 15 mg primaquine daily (dotted line). Data are from a study by Alving et al. (2).
See this image and copyright information in PMC

References

    1. Alving A. S., Craige B., Jr., Pullman T. N., Whorton C. M., Jones R., Jr., Eichelberger L. 1948. Procedures used at Stateville Penitentiary for the testing of potential antimalarial drugs. J. Clin. Invest. 27:2–5 - PMC - PubMed
    1. Alving A. S., et al. 1955. Potentiation of the curative action of primaquine in vivax malaria by quinine and chloroquine. J. Lab. Clin. Med. 46:301–306 - PubMed
    1. Alving A. S., et al. 1948. The clinical trial of eighteen analogues of pamaquin (plasmochin) in vivax malaria (Chesson strain). J. Clin. Invest. 27:34–45 - PubMed
    1. Andrade B. B., et al. 2010. Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance. Malaria J. 9:13 - PMC - PubMed
    1. Baird J. K. 2009. Resistance to therapies for infection by Plasmodium vivax. Clin. Microbiol. Rev. 22:508–534 - PMC - PubMed

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