doi: 10.1126/science.213832.
Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase
- PMID: 213832
- DOI: 10.1126/science.213832
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Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase
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Abstract
C6 glioma cells and B104 neuroblastoma cells both possess adenylate cyclase activity, but only C6 cells have beta-adrenergic receptors. However, when cocultured with B104 cells, C6 cells show a marked decrease in their ability to accumulate adenosine 3', 5'-monophosphate upon stimulation with beta receptor agonists. Since both beta receptors and cholera toxin-stimulated adenylate cyclase activities are present in C6/B104 cocultures, we conclude that the beta receptor/adenylate cyclase transduction mechanism in cocultured C6 cells is uncoupled.
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