Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jan;25(1):69-72.
doi: 10.1093/jac/25.1.69.

In-vitro selection of resistance of Staphylococcus aureus to teicoplanin and vancomycin

Affiliations

In-vitro selection of resistance of Staphylococcus aureus to teicoplanin and vancomycin

C Watanakunakorn. J Antimicrob Chemother. 1990 Jan.

Abstract

Nineteen strains of Staphylococcus aureus (five penicillin-susceptible and methicillin-susceptible, four methicillin-susceptible and penicillin-resistant, and ten methicillin-resistant) were serially subcultured in broth media containing a subinhibitory concentration (half the MIC) of either teicoplanin or vancomycin. The MIC of the antibiotic was again measured after five passages in antibiotic-containing broth. The experiment was terminated after 25 passages. After passage fifteen strains exhibited an eight-fold or greater increase in MIC of teicoplanin. On the other hand, only two strains exhibited even an unstable four-fold increase in MIC of vancomycin.

PubMed Disclaimer

MeSH terms

LinkOut - more resources