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Editorial
. 2011 May;300(5):C968-9.
doi: 10.1152/ajpcell.00059.2011. Epub 2011 Mar 9.

Nitric oxide-induced collagen IV expression and angiogenesis: FAK or fiction? Focus on "Collagen IV contributes to nitric oxide-induced angiogenesis of lung endothelial cells"

James A Stewart Jr, T Aaron West, Pamela A Lucchesi
Editorial

Nitric oxide-induced collagen IV expression and angiogenesis: FAK or fiction? Focus on "Collagen IV contributes to nitric oxide-induced angiogenesis of lung endothelial cells"

James A Stewart Jr et al. Am J Physiol Cell Physiol. 2011 May.
No abstract available

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Figures

Fig. 1.
Fig. 1.
A central role for nitric oxide (NO) in angiogenesis. NO production via endothelial NO synthase (eNOS) is regulated by endothelin (ET-1) interactions with the ETB receptor, VEGF/VEGF receptor (VEGFR2), as well as shear stress (not shown). NO-cGMP regulates the expression of collagen IV, matrix metalloproteinase (MMP)-9, and α1β1 and αvβ3 and modulates VEGF, integrin, and angiopoietin (Ang) signaling. Collagen IV interacts with α1β1; MMP-9 cleavage exposes an αvβ3 cryptic binding site (tumstatin) that may limit angiogenesis. p-FAK, phosphorylated focal adhesion kinase.
See this image and copyright information in PMC

Comment on

References

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