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. 2011;75(3):593-5.
doi: 10.1271/bbb.100710. Epub 2011 Mar 7.

Soy isoflavone equol perpetuates dextran sulfate sodium-induced acute colitis in mice

Tohru Sakai  1 , Sakina Furoku, Mariko Nakamoto, Emi Shuto, Toshio Hosaka, Yasuhiko Nishioka, Saburo Sone
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Free article

Soy isoflavone equol perpetuates dextran sulfate sodium-induced acute colitis in mice

Tohru Sakai et al. Biosci Biotechnol Biochem. 2011.
Free article

Abstract

The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract.

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