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. 2011;33(4):298-304.
doi: 10.1159/000324847. Epub 2011 Mar 8.

Serum uric acid level and endothelial dysfunction in patients with nondiabetic chronic kidney disease

Mehmet Kanbay  1 , Mahmut Ilker Yilmaz, Alper Sonmez, Faruk Turgut, Mutlu Saglam, Erdinc Cakir, Mujdat Yenicesu, Adrian Covic, Diana Jalal, Richard J Johnson
Affiliations

Serum uric acid level and endothelial dysfunction in patients with nondiabetic chronic kidney disease

Mehmet Kanbay et al. Am J Nephrol. 2011.

Abstract

Background: An elevated serum uric acid level is strongly associated with endothelial dysfunction and inflammation, both of which are common in chronic kidney disease (CKD). We hypothesized that endothelial dysfunction in subjects with CKD would correlate with uric acid levels.

Materials and methods: We evaluated the association between serum uric acid level and ultrasonographic flow-mediated dilatation (FMD) in 263 of 486 patients with recently diagnosed CKD (stage 3-5) (48% male, age 52 ± 12 years). To minimize confounding, 233 patients were excluded because they were diabetic, had established cardiovascular complications or were taking drugs (renin-angiotensin system blockers, statins) interfering with vascular function.

Results: Serum uric acid level was significantly increased in all stages of CKD and strongly correlated with estimated glomerular filtration rate (eGFR-MDRD); FMD was inversely associated with serum uric acid (r = -0.49, p < 0.001). The association of serum uric acid with FMD remained after adjustment for age, gender, smoking, LDL cholesterol, eGFR, high-sensitivity C-reactive protein, systolic blood pressure, proteinuria, and homeostatic model assessment index (β = -0.27, p < 0.001).

Conclusion: Increased serum uric acid is an independent predictor of endothelial dysfunction in subjects with CKD.

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Figures

Fig. 1
Fig. 1
Flow diagram of the study population.
Fig. 2
Fig. 2
Correlation between FMD and uric acid in patients with CKD stage 3–5.
See this image and copyright information in PMC

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