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. 1990 Jan 1;54(1-3):129-33.
doi: 10.1016/0378-1097(90)90270-z.

Correlation between the effects of fosfomycin and chloramphenicol on Escherichia coli

D Mengin-Lecreulx  1 , J van Heijenoort
Affiliations

Correlation between the effects of fosfomycin and chloramphenicol on Escherichia coli

D Mengin-Lecreulx et al. FEMS Microbiol Lett. .

Abstract

It was speculated that the increase of the UDP-GlcNAc pool observed with chloramphenicol can modulate the residual PEP:UDP-GlcNAc-enolpyruvate activity of fosfomycin-treated cells. This provided an explanation on how chloramphenicol can insure the formation of enough UDP-MurNAc-pentapeptide to sustain peptidoglycan synthesis at a rate that will antagonize fosfomycin-induced lysis.

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