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Comparative Study
. 2011 Aug;20(4):370-2.
doi: 10.1016/j.breast.2011.02.011. Epub 2011 Mar 10.

Clinicopathologic characteristics and prognosis of young patients with breast cancer

Ji-guang Han  1 , Yong-dong Jiang, Chun-hui Zhang, Da Pang, Ming Zhang, Yan-bo Wang, Wei-nan Xue, Qian Sun
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Free article
Comparative Study

Clinicopathologic characteristics and prognosis of young patients with breast cancer

Ji-guang Han et al. Breast. 2011 Aug.
Free article

Abstract

Background: The aim was to describe the clinicopathological features and prognosis of young patients with breast cancer.

Patients and methods: We reviewed the records of 1478 consecutive patients aged ≤50 years with first diagnosis of invasive breast cancer referred to surgery from January 1999 to March 2005. A total of 174 patients were aged <35 years (group I) and 1304 were aged 35-50 years (group II).

Results: Compared with patients of group II, patients of group I had a higher percentage of tumors classified as estrogen receptors (ER) negative, progesterone receptors (PR) negative, with a Ki-67 labeling index ≥20% of the cells. The 5-year survival of group I was 78.3% as compared with 84.2% for group II (P = 0.006).

Conclusion: Compared with patients aged between 35 and 50 years, patients aged <35 years have a greater chance of having an endocrine-unresponsive tumor and a significantly poor prognosis.

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