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Review
. 2011 Feb;11(1):29-33.
doi: 10.1016/j.coph.2011.02.004. Epub 2011 Mar 8.

5-HT and the immune system

Gerard P Ahern  1
Affiliations
Review

5-HT and the immune system

Gerard P Ahern. Curr Opin Pharmacol. 2011 Feb.

Abstract

The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the central nervous system in immune signaling. Here I review recent studies describing 5-HT uptake in dendritic cells and B lymphocytes, 5-HT synthesis in T lymphocytes, and the role of specific 5-HT receptor subtypes in innate and adaptive immune cells. Furthermore, a recent paper describing the immune phenotype of 5-HT deficient mice is discussed.

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Figures

Figure 1
Figure 1
Summary of 5-HT synthesis, 5-HT transport and 5-HT receptor subtypes in different immune cells. The known signaling roles for SERT (effects of SSRIs) and 5-HT receptors are listed for each cell.
See this image and copyright information in PMC

References

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