[Effect of dipeptide neurotensin analog dilept on extracellular concentrations of glutamate, GABA and HVA in N. accumbens of rat brain]

Abstract

The influence of dilept (GZR-123, N-caproyl-L-prolyl-L-tyrosine methyl ester)--a dipeptide analog of neurotensin (NT)--on extracellular concentration of glutamate, gamma-aminobutyric acid (GABA) and homovanillic acid (HVA) in n. accumbens of Wistar rats has been studied. By means of microdialysis, it was shown that dilept increases the concentrations of glutamate and GABA and decreases the HVA content in n. accumbens. These effects of dilept are similar to those produced by NT introduced into n. accumbens. Thus, dilept can be considered as a systemically active dipeptide analog of NT, which is capable of modulating the dysbalance of glutamate-, GABA-, and dopaminergic systems of n. accumbens. These neurochemical data taken together with previously established behavioral effects of dilept suggest that this dipeptide is a potential antipsychotic drug.