Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2011 Jun;151(6):999-1006.e4.
doi: 10.1016/j.ajo.2010.11.029. Epub 2011 Mar 10.

Association of host genetic risk factors with the course of cytomegalovirus retinitis in patients infected with human immunodeficiency virus

Efe Sezgin  1 , Mark L van Natta, Alka Ahuja, Alice Lyon, Sunil Srivastava, Jennifer L Troyer, Stephen J O'Brien, Douglas A Jabs; Studies of the Ocular Complications of AIDS Research Group
Collaborators, Affiliations
Multicenter Study

Association of host genetic risk factors with the course of cytomegalovirus retinitis in patients infected with human immunodeficiency virus

Efe Sezgin et al. Am J Ophthalmol. 2011 Jun.

Abstract

Purpose: To evaluate the effects of previously reported host genetics factors that influence cytomegalovirus (CMV) retinitis incidence, progression to acquired immune deficiency syndrome (AIDS), and efficacy of highly active antiretroviral therapy (HAART) for mortality, retinitis progression, and retinal detachment in patients with CMV retinitis and AIDS in the era of HAART.

Design: Prospective, multicenter, observational study.

Methods: Cox proportional hazards model based genetic association tests examined the influence of IL-10R1_S420L, CCR5-Δ32, CCR2-V64I, CCR5 promoter, and SDF-3'A polymorphisms among patients with mortality, retinitis progression, and retinal detachment. Participants were 203 European-American and 117 African-American patients with AIDS and CMV retinitis.

Results: European-American patients with the CCR5 +.P1.+ promoter haplotype showed increased risk for mortality (hazard ratio [HR] = 1.83; 95% confidence interval [CI]: 1.00-3.40; P = .05). Although the same haplotype also trended for increased risk for mortality in African-American patients, the result was not significant (HR = 2.28; 95% CI: 0.93-5.60; P = .07). However, this haplotype was associated with faster retinitis progression in African Americans (HR = 5.22; 95% CI: 1.54-17.71; P = .007). Increased risk of retinitis progression was also evident for African-American patients with the SDF1-3'A variant (HR = 3.89; 95% CI: 1.42-10.60; P = .008). In addition, the SDF1-3'A variant increased the retinal detachment risk in this patient group (HR = 3.05; 95% CI: 1.01-9.16; P = .05).

Conclusion: Besides overall immune health, host genetic factors influence mortality, retinitis progression, and retinal detachment in patients with AIDS and CMV retinitis that are receiving HAART.

PubMed Disclaimer

Conflict of interest statement

None of the authors have conflict of interest with any aspect of this study.

Figures

Figure 1
Figure 1
Kaplan-Meier plots comparing retinitis progression among Cytomegalovirus Retinitis diagnosed African American LSOCA patients with CCR5 +.p1.+ promoter haplotype (Left) and SDF1-3′A variant against other genotypes (Right).
See this image and copyright information in PMC

References

    1. Gallant JE, Moore RD, Richman DD, Keruly J, Chaisson RE. Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. The Zidovudine Epidemiology Study Group. J Infect Dis. 1992;166(6):1223–1227. - PubMed
    1. Hoover DR, Peng Y, Saah A, et al. Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression. Arch Ophthalmol. 1996;114(7):821–827. - PubMed
    1. Jabs DA. Ocular manifestations of HIV infection. Trans Am Ophthalmol Soc. 1995;93:623–683. - PMC - PubMed
    1. Pertel P, Hirschtick R, Phair J, et al. Risk of developing cytomegalovirus retinitis in persons infected with the human immunodeficiency virus. J Acquir Immune Defic Syndr. 1992;5(11):1069–1074. - PubMed
    1. Studies of ocular complications of AIDS (LSOCA) Research Group ACTGA. Studies of ocular complications of AIDS Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial: 1. Rationale, design, and methods. Control Clin Trials. 1992;13(1):22–39. - PubMed

Publication types

MeSH terms