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Comment
. 2011 Mar 8;19(3):299-300.
doi: 10.1016/j.ccr.2011.03.001.

SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF

Paul T Schumacker  1
Affiliations
Comment

SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF

Paul T Schumacker. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Finley and coworkers report that the genetic loss of the deacetylase SIRT3 leads to metabolic reprogramming toward glycolysis. This shift is mediated by an increase in cellular reactive oxygen species (ROS) generation that amplifies HIF-α stabilization and HIF-dependent gene expression, thereby driving the tumor phenotype.

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Figures

Figure 1
Figure 1
Regulation of tumor cell phenotype by SIRT3.
See this image and copyright information in PMC

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References

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