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. 2011 Jan 14:3:1.
doi: 10.3410/B3-1.

At home with hostility: How do pathogenic bacteria evade mammalian immune surveillance to establish persistent infection?

Thomas Ruby  1 , Denise M Monack
Affiliations

At home with hostility: How do pathogenic bacteria evade mammalian immune surveillance to establish persistent infection?

Thomas Ruby et al. F1000 Biol Rep. .

Abstract

Bacterial persistence is of major concern as persistent bacterial infections involving bacteria such as Helicobacter pylori, Salmonella enterica serotype Typhi, and Mycobacterium tuberculosis pose significant public health problems worldwide. This report discusses the recent advances in understanding the strategies used by bacteria during persistent infection that allow them to colonize specific sites in the host and evade immune surveillance.

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References

    1. Kingsley RA, Msefula CL, Thomson NR, Kariuki S, Holt KE, Gordon MA, Harris D, Clarke L, Whitehead S, Sangal V, Marsh K, Achtman M, Molyneux ME, Cormican M, Parkhill J, MacLennan CA, Heyderman RS, Dougan G. Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype. Genome Res. 2009;19:2279–87. doi: 10.1101/gr.091017.109. - DOI - PMC - PubMed

    2. F1000 Factor 6

      Evaluated by Andreas Baumler 20 Apr 2010

    1. Tan S, Tompkins LS, Amieva MR. Helicobacter pylori usurps cell polarity to turn the cell surface into a replicative niche. PLoS Pathog. 2009;5:e1000407. doi: 10.1371/journal.ppat.1000407. - DOI - PMC - PubMed

    2. F1000 Factor 9

      Evaluated by Jay Solnik 01 Sep 2009

    1. Lawley TD, Chan K, Thompson LJ, Kim CC, Govoni GR, Monack DM. Genome-wide screen for Salmonella genes required for long-term systemic infection of the mouse. PLoS Pathog. 2006;2:e11. doi: 10.1371/journal.ppat.0020011. - DOI - PMC - PubMed

    2. F1000 Factor 6

      Evaluated by Francisco Garcia-del Portillo 14 Mar 2006

    1. McLaughlin LM, Govoni GR, Gerke C, Gopinath S, Peng K, Laidlaw G, Chien YH, Jeong HW, Li Z, Brown MD, Sacks DB, Monack D. The Salmonella SPI2 effector SseI mediates long-term systemic infection by modulating host cell migration. PLoS Pathog. 2009;5:e1000671. doi: 10.1371/journal.ppat.1000671. - DOI - PMC - PubMed

    2. F1000 Factor 6

      Evaluated by Virginia Miller 06 Jan 2010

    1. Russell DG, Cardona PJ, Kim MJ, Allain S, Altare F. Foamy macrophages and the progression of the human tuberculosis granuloma. Nat Immunol. 2009;10:943–8. doi: 10.1038/ni.1781. - DOI - PMC - PubMed