Essential ingredients for HIV-1 budding
- PMID: 21402355
- DOI: 10.1016/j.chom.2011.03.005
Essential ingredients for HIV-1 budding
Abstract
HIV-1 engages the cellular ESCRT-III/VPS4 membrane scission machinery for its escape from host cells. Three papers now begin to demystify its mode of action by showing that HIV-1 requires only the transient recruitment of a surprisingly small subset of ESCRT-III components, whose membrane abscission function depends on VPS4 activity.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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ESCRT-III protein requirements for HIV-1 budding.Cell Host Microbe. 2011 Mar 17;9(3):235-242. doi: 10.1016/j.chom.2011.02.004. Cell Host Microbe. 2011. PMID: 21396898 Free PMC article.
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