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Comment
. 2011 Mar 17;9(3):172-174.
doi: 10.1016/j.chom.2011.03.005.

Essential ingredients for HIV-1 budding

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Essential ingredients for HIV-1 budding

Winfried Weissenhorn et al. Cell Host Microbe. .
Free article

Abstract

HIV-1 engages the cellular ESCRT-III/VPS4 membrane scission machinery for its escape from host cells. Three papers now begin to demystify its mode of action by showing that HIV-1 requires only the transient recruitment of a surprisingly small subset of ESCRT-III components, whose membrane abscission function depends on VPS4 activity.

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  • ESCRT-III protein requirements for HIV-1 budding.
    Morita E, Sandrin V, McCullough J, Katsuyama A, Baci Hamilton I, Sundquist WI. Morita E, et al. Cell Host Microbe. 2011 Mar 17;9(3):235-242. doi: 10.1016/j.chom.2011.02.004. Cell Host Microbe. 2011. PMID: 21396898 Free PMC article.

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