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. 2011 Jun;55(6):3008-11.
doi: 10.1128/AAC.00416-10. Epub 2011 Mar 14.

Changes in antibiotic distribution due to pancreatitis

Kent J Fanning  1 , Thomas A Robertson, Johannes B Prins, Michael S Roberts
Affiliations

Changes in antibiotic distribution due to pancreatitis

Kent J Fanning et al. Antimicrob Agents Chemother. 2011 Jun.

Abstract

This work sought to define how pancreatitis affected antibiotic distribution in a perfused rat pancreas model. The distribution kinetics of four antibiotics were examined in control animals and animals with pancreatitis. Meropenem and piperacillin distributed into the extracellular space, and their distribution kinetics were unaffected by pancreatitis. In contrast, in pancreatic cells from animals with pancreatitis, ciprofloxacin showed a reduced uptake and clindamycin showed a reduced distribution.

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Figures

Fig. 1.
Fig. 1.
Typical fit of outflow profile data of antibiotics in control and diseased animals. (A to D) Outflow profile data of piperacillin (A), meropenem (B), ciprofloxacin (C), and clindamycin (D) in control (●) and diseased (○) animals. The lines indicate the fitted curves applying a physiologically based pharmacokinetic model.
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