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. 2011 May;55(5):2478-80.
doi: 10.1128/AAC.01560-10. Epub 2011 Mar 14.

Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema

Brad Moriyama  1 , Marisa Ditullio, Eleanor Wilson, Stacey A Henning, Scott R Penzak, Robert L Danner, Gennethel Pennick, Michael G Rinaldi, Adrian M Zelazny, Juan Gea-Banacloche, A John Barrett, Thomas J Walsh
Affiliations

Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema

Brad Moriyama et al. Antimicrob Agents Chemother. 2011 May.

Abstract

Candida empyema is a serious complication of disseminated candidiasis. However, little is known about the intrapleural pharmacokinetics of echinocandins. We report the penetration of anidulafungin into the pleural fluid of a patient with Candida tropicalis empyema. The anidulafungin ratio for the area under the concentration-time curve from 0 h to the last measurement between pleural fluid and serum values was only 0.125 (12.5%), with pleural fluid concentrations ranging between 0.67 and 0.88 μg/ml.

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Figures

Fig. 1.
Fig. 1.
Serum and pleural fluid concentration-versus-time profiles of a dose of anidulafungin (100 mg i.v. every 24 h; an actual dose of 88.62 mg was delivered on the day of pharmacokinetic sampling due to drug left in the intravenous tubing).
See this image and copyright information in PMC

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