Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 May;57(5):873-9.
doi: 10.1161/HYPERTENSIONAHA.108.120246. Epub 2011 Mar 14.

Sodium reabsorption in the thick ascending limb in relation to blood pressure: a clinical perspective

Jeesun Jung  1 , David P Basile, J Howard Pratt
Affiliations
Review

Sodium reabsorption in the thick ascending limb in relation to blood pressure: a clinical perspective

Jeesun Jung et al. Hypertension. 2011 May.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic depiction of a TAL tubular cell’s uptake of ions by the Na+,K+,2Cl−cotransporter (NKCC2). Loss-of-function mutations in the genes for NKCC2, ROMK, CLCNKB or BSND account for, respectively, Types 1–4 Bartter’s syndrome; a gain-of-function mutation in the CASR gene results in Type 5 Bartter’s syndrome. A deficiency in ROMK inhibits NKCC2 because of less K+ available to the cotransporter (K+ availability is rate-limiting); less luminal K+ results in a more negative charge that keeps Ca++ in solution thereby favoring its excretion (as opposed to its paracellular uptake). CLCNKB and BSNB are required for maintaining efflux of Cl− and are rate-limiting for the optimal function of the cotransporter. Activation of CASR by extracellular Ca++ has an effect to inhibit indirectly the cotransporter. ROMK = K+ channel; CLCNKB = Cl− channel; BSND = Bartter’s syndrome, infantile, with sensorneural deafness; also known as barttin; and CASR = Ca++ -sensing receptor.
See this image and copyright information in PMC

References

    1. Egan BM, Zhao Y, Axon RN. US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008. JAMA. 2010;303:2043–2050. - PubMed
    1. Guyton AC, Coleman TG. Regulation on interstitial fluid volume and pressure. Ann N Y Acad Sci. 1968;150:537–547. - PubMed
    1. Hall JE, Mizelle L, Hildebrandt DA, Brands MW. Abnormal pressure natriuresis. A cause or consequence of hypertension? Hypertension. 1990;15:547–559. - PubMed
    1. Hebert SC, Andreoli TE. Control of NaCl transport in the thick ascending limb. Am J Physiol. 1984;246:F745–F756. - PubMed
    1. Bartter FC, Pronove P, Gill JR, MacCardle RC. Hyperplasia of the jutaglomerular complex wih hyperaldosteronism and hypokalemic alkalosis. Am J Med. 1962;33:811–828. - PubMed

Publication types