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Review
. 2011 Mar 15;123(10):1116-24.
doi: 10.1161/CIRCULATIONAHA.110.943860.

Evaluating the clinical utility of a biomarker: a review of methods for estimating health impact

Mark J Pletcher  1 , Michael Pignone
Affiliations
Review

Evaluating the clinical utility of a biomarker: a review of methods for estimating health impact

Mark J Pletcher et al. Circulation. .
No abstract available

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Figures

Figure 1
Figure 1
Three mechanisms by which biomarker measurement may improve health outcomes
Figure 2
Figure 2
Fundamental design for a randomized trial to evaluate biomarker utility
Figure 3
Figure 3. Decision analytic framework for modeling clinical utility of a biomarker
The square node represents the “decision node”; in this example, four different strategies are evaluated (S1-S4). Round nodes are “probability nodes”. In this framework, the round nodes indicate a split of the patient group into subgroups defined by the underlying distribution of the biomarker in the patient group. Note that the probabilities of having a high, medium or low biomarker result are the same for each strategy within this scenario, but may be different in different scenarios.
See this image and copyright information in PMC

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