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. 2010:2010:847632.
doi: 10.1155/2010/847632. Epub 2011 Feb 13.

Levels of salivary IFN-gamma, TNF-alfa, and TNF receptor-2 as prognostic markers in (erosive) oral lichen planus

Noha A Ghallab  1 , Naglaa el-Wakeel, Olfat G Shaker
Affiliations

Levels of salivary IFN-gamma, TNF-alfa, and TNF receptor-2 as prognostic markers in (erosive) oral lichen planus

Noha A Ghallab et al. Mediators Inflamm. 2010.

Abstract

To explore the feasibility of detecting salivary levels of IFN-γ, TNF-α, and sTNFR-2 from erosive oral lichen planus (ELP) patients for clinical application, 20 ELP patients were enrolled in the study as were 20 age-sex-matched controls. From all subjects, saliva level of the tested biomarkers was determined by ELISA. Salivary profiles were assessed in ELP patients by ELISA after being treated with prednisone. A significantly higher level of IFN-γ (P ≤ .01), TNF-α (P ≤ .0001), and sTNFR-2 (P ≤ .01) was detected in ELP patients before treatment than in controls. Following treatment, the salivary levels of IFN-γ (P ≤ .01), TNF-α (P ≤ .05), and sTNFR-2 (P ≤ .01) decreased significantly when compared to their pretreatment levels. This study demonstrated that salivary IFN-γ, TNF-α, and sTNFR-2 can be detectable in ELP patients and decreased significantly after treatment with prednisone, which may reveal the possibility of using these disease-related biomarkers in diagnosis and monitoring.

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Figures

Figure 1
Figure 1
Salivary levels of IFN-γ measured in pg/mL from control subjects compared with levels in ELP patients before and after treatment with prednisone.
Figure 2
Figure 2
Salivary levels of TNF-α measured in pg/mL from control subjects compared with levels in ELP patients before and after treatment with prednisone.
Figure 3
Figure 3
Salivary levels of sTNFR-2 measured in pg/mL from control subjects compared with levels in ELP patients before and after treatment with prednisone.
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