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Case Reports
. 2011 Apr;26(4):1438.
doi: 10.1093/ndt/gfr019. Epub 2011 Mar 15.

Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis

Stephen Harding  1 , Francois Provot, Jean-Baptise Beuscart, Mark Cook, Arthur R Bradwell, Stephanie Stringer, Darren White, Paul Cockwell, Colin A Hutchison
Affiliations
Case Reports

Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis

Stephen Harding et al. Nephrol Dial Transplant. 2011 Apr.

Abstract

Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.

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